Vol. 29/2020 Nr 59
okładka czasopisma Child Neurology
powiększenie okładki
Informacje o Pismie

NEUROLOGIA DZIECIĘCA

Pismo Polskiego Towarzystwa Neurologów Dziecięcych

PL ISSN 1230-3690
e-ISSN 2451-1897
DOI 10.20966
Półrocznik


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Cortisol in individuals with autism spectrum disorders – review


Kortyzol u osób z zaburzeniami ze spektrum autyzmu - przegląd piśmiennictwa




Department of Infectious Diseases and Child Neurology, Poznan University of Medical Sciences, Poland

https://doi.org/10.20966/chn.2020.59.467
Neurol Dziec 2020; 29, 59: 36-44
Pełen tekst artykułu PDF Cortisol in individuals with autism spectrum disorders – review



ABSTRACT
Cortisol is a hormone crucial for homeostasis of the human organism. Many researchers proved the role of cortisol and its normal release rhythm in healthy individuals. It led to further investigations of the abnormalities in cortisol levels in those affected by various disorders , especially with neuropsychiatric symptoms. Autism spectrum disorder is one of these conditions which have been intensively researched due to its core and secondary symptoms. We conducted a systematic review of articles in PubMed, including papers that met the search criteria “autism” and “cortisol”. After initial selection of relevant papers, we analyzed data from 56 articles. We divided data into subcategories of studies concerning cortisol diurnal profile, basal cortisol levels, Cortisol Awakening Response (CAR) and cortisol levels in reaction to certain stimuli. Data was unequivocal, however, abnormal diurnal profile, basal level, CAR or stressor response were found in many research groups. It led to suspicion that the abnormalities of cortisol release are a widely-spread phenomenon among individuals with autism spectrum disorder. Very limited data from therapeutic interventions indicated more clinical than biological response. This systematic review should be a drive to action for further randomized clinical trial on larger, homogenous group of patients to obtain more thorough insight into the role of cortisol in autism spectrum disorder.

Key words: cortisol, autism spectrum disorder, children


STRESZCZENIE
Kortyzol jest jednym z kluczowych hormonów dla zachowania homeostazy w organizmie człowieka, co zostało wykazane w wielu badaniach u osób zdrowych. Zbadano również prawidłowy rytm uwalniania kortyzolu. Stanowi to podstawę do dalszych badań zaburzeń wydzielania kortyzolu w różnych schorzeniach, szczególnie tych objawiających się zaburzeniami neuropsychiatrycznymi. Zaburzenia ze spektrum autyzmu stanowią jeden z najintensywniej badanych problemów zdrowotnych ze względu na objawy osiowe autyzmu, takie jak lęk czy zaburzenia społeczne i zachowania, jak również dodatkowe objawy, takie jak zaburzenia snu czy czynnościowe przewodu pokarmowego. Przeprowadziliśmy systematyczny przegląd piśmiennictwa w bazie PubMed, uwzględniając artykuły spełniające kryteria wyszukiwania “autism” (autyzm) i “cortisol” (kortyzol). Po pierwotnej selekcji istotnych prac, przeanalizowaliśmy 56 artykułów. Omawianie wyników podzieliliśmy na podkategorie, dotyczące profilu dobowego kortyzolu, podstawowych jego poziomów, wydzielania przy obudzeniu oraz poziomów w reakcji na konkretny bodziec. Analizowane dane były niejednoznaczne. Zaburzenia profilu dobowego kortyzolu, podstawowego jego poziomu, wydzielania przy obudzeniu oraz poziomów w reakcji na stresor stanowiły jednakże częste zjawisko wśród badanych osób z zaburzeniami ze spektrum autyzmu. Nieliczne dane dotyczące wpływu prowadzonych działań terapeutycznych wskazywały na częściej osiąganą kliniczną poprawę niż zmiany w stężeniu kortyzolu. Poniższy przegląd piśmiennictwa powinien stanowić podstawę do przeprowadzenia randomizowanych badań klinicznych na dużej, homogennej grupie, by uzyskać bardziej wnikliwe spojrzenie na rolę kortyzolu w zaburzeniach ze spektrum autyzmu.

Słowa kluczowe: kortyzol, autyzm, dzieci


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