Vol. 30-31/2021-2022 Nr 60
okładka czasopisma Child Neurology
powiększenie okładki
Informacje o Pismie

NEUROLOGIA DZIECIĘCA

Pismo Polskiego Towarzystwa Neurologów Dziecięcych

PL ISSN 1230-3690
e-ISSN 2451-1897
DOI 10.20966
Półrocznik


Powrót

Narcolepsy in children


Narkolepsja u dzieci




1Polysomnography and Sleep Research Unit, Department of Developmental Neurology, Poznan University of Medical Sciences
2 Department of Developmental Neurology, Poznan University of Medical Sciences
3 Department of Neurology, New York University, Langone Medical School

Neurol Dziec 2014; 23, 47: 9-19
Pełen tekst artykułu PDF Narcolepsy in children



ABSTRACT
Narcolepsy is a life-long but non-progressive neurological disorder characterized by excessive daytime sleepiness and increased presence of rapid eye movement (REM) sleep due to loss of hypocretin containing neurons located in the lateral hypothalamus. According to the International Classification of Sleep Disorders, Third Edition (ICSD-3), narcolepsy is typically associated with cataplexy and/or other REM sleep phenomena such as hypnagogic or hypnopompic hallucinations and sleep paralysis. Narcolepsy is not an uncommon disorder, but is under-recognized. The age of onset shows two peaks of presentation: in childhood and in adults. Both genetics and environmental factors may be involved in the development of narcolepsy. The history, combined with polysomnography and MSLT, remain the current gold standard in the diagnosis of narcolepsy. The levels of Hypocretin-1 are undetectable in the cerebrospinal fluid in most patients with narcolepsy with cataplexy. Early recognition and treatment can greatly improve the quality of life of patients with narcolepsy. Treatment of narcolepsy includes non-pharmacological treatment (life style changes) and pharmacological (stimulants, modafinil, sodium oxybate) against hypersomnia and anticataplectic drugs (antidepressants and sodium oxybate).

Key words: sleep, narcolepsy, cataplexy, sleepiness, children


STRESZCZENIE
Narkolepsja jest przewlekłą, niepostępującą chorobą neurologiczną charakteryzującą się nadmierną sennością w ciągu dnia oraz objawami związanymi ze zwiększeniem ilości snu z szybkim ruchem gałek ocznych (REM), spowodowaną utratą neuronów hipokretynowych zlokalizowanych w bocznej części podwzgórza. Zgodnie z Międzynarodową Klasyfikacją Zaburzeń Snu – wersją trzecią (ICSD-3) narkolepsja typowo jest skojarzona z katapleksją i/lub innymi zjawiskami związanymi ze snem REM takimi jak halucynacje hipnagogiczne i hipnopompiczne czy paraliż przysenny. Narkolepsja nie jest rzadką chorobą, często nie jest jednak rozpoznawana. Obserwowane są dwa szczyty zachorowania: w dzieciństwie i w wieku dorosłym. W etiopatogenezie narkolepsji mają znaczenie zarówno czynniki genetyczne, jak i środowiskowe. W diagnostyce narkolepsji największe znaczenie ma wywiad, a test wielokrotnej latencji snu (MSLT) poprzedzony całonocną polisomnografią uznawany jest za złoty standard w diagnostyce narkolepsji. Poziom hipokretyny-1 w płynie mózgowo-rdzeniowym u większości pacjentów z narkolepsją z katapleksją jest nieoznaczalny. Wczesne rozpoznanie i leczenie może wpłynąć znacząco na poprawę jakości życia pacjentów z narkolepsją. W leczeniu bierze się pod uwagę interwencje niefarmakologiczne (modyfikacje stylu życia) oraz farmakologiczne: stymulanty, modafinil, hydroksymaślan sodu w leczeniu nadmiernej senności oraz antydepresanty i hydroksymaślan sodu w leczeniu katapleksji.

Słowa kluczowe: sen, narkolepsja, katapleksja, senność, dzieci


BIBLIOGRAPHY
[1] 
International Classification of Sleep Disorders, 3rd ed. American Academy of Sleep Medicine, Darien, IL 2014.
[2] 
The international classification of sleep disorders diagnostic and coding manual 2nd ed. American Academy of Sleep Medicine, Westchester, IL 2005.
[3] 
Guilleminault C., Pelayo R.: Narcolepsy in children: a practical guide to its diagnosis, treatment and follow-up. Paediatr Drugs 2000; 2: 1–9.
[4] 
Nevsimalova S.: Narcolepsy in childhood. Sleep Med Rev 2009; 13: 169–180.
[5] 
Schenck C.H., Bassetti C.L., Arnulf I., et al.: English translations of the first clinical reports on narcolepsy and cataplexy by Westphal and Gelineau in the late 19th century, with commentary. J Clin Sleep Med 2007; 3: 301–311.
[6] 
Gélineau J.: De la narcolepsie. Gaz Hôp Civil Milit 1880; 53: 626–628, 635–637.
[7] 
Daniels L.: Narcolepsy. Medicine 1934; 13: 122.
[8] 
Mignot E.: A hundred years of narcolepsy research. Arch Ital Biol 2001; 139: 207–220.
[9] 
Yoss R.E., Daly D.D.: Criteria for the diagnosis of the narcoleptic syndrome. Proc Staff Meet Mayo Clin 1957; 32: 320–328.
[10] 
Vogel G.: Studies in psychophysiology of dreams. III. The dream of narcolepsy. Arch Gen Psychiatry 1960; 3: 421–428.
[11] 
Ohayon M.M., Ferini-Strambi L., Plazzi G., et al.: How age influences the expression of narcolepsy. J Psychosom Res 2005; 59: 399–405.
[12] 
Nevsimalova S., Buskova J., Kemlink D., et al.: Does age at the onset of narcolepsy influence the course and severity of the disease? Sleep Med 2009; 10: 967–972.
[13] 
Dauvilliers Y., Montplaisir J., Molinari N., et al.: Age at onset of narcolepsy in two large populations of patients in France and Quebec. Neurology 2001; 57: 2029–2033.
[14] 
Thorpy M.: Current concepts in the etiology, diagnosis and treatment of narcolepsy. Sleep Med 2001; 2: 5–17.
[15] 
Ohayon M.M., Priest R.G., Zulley J., et al.: Prevalence of narcolepsy symptomatology and diagnosis in the European general population. Neurology 2002; 58: 1826–1833.
[16] 
Hublin C., Kaprio J., Partinen M., et al.: The prevalence of narcolepsy: an epidemiological study of the Finnish Twin Cohort. Ann Neurol 1994; 35: 709–716.
[17] 
Oksenberg J., Amar A., Cohen N., et al.: HLA-D „BG” in Israel. A Japanese related allele population and family study. Tissue Antigens 1983; 21: 271–280.
[18] 
Lavie P., Peled R.: Narcolepsy is a rare disease in Israel. Sleep 1987; 10: 608–609.
[19] 
Wilner A., Steinman L., Lavie P., et al.: Narcolepsy-cataplexy in Israeli Jews is associated exclusively with the HLA DR2 haplotype. A study at the serological and genomic level. Hum Immunol 1988; 21: 15-22.
[20] 
Honda K.: Census of narcolepsy, cataplexy and sleep life among teenagers in Fujisawa City. Sleep Res 1979; 8.
[21] 
Tashiro T., Kanbayashi T., Iijima S., et al.: An epidemiological study on prevalence of narcolepsy in Japanese. J Sleep Res 1992; 1.
[22] 
Guilleminault C., Mignot E., Grumet F.C.: Familial patterns of narcolepsy. Lancet 1989; 2: 1376-1379.
[23] 
Billiard M., Pasquie-Magnetto V., Heckman M., et al.: Family studies in narcolepsy. Sleep 1994; 17: 54-59.
[24] 
Baraitser M., Parkes J.D.: Genetic study of narcoleptic syndrome. J Med Genet 1978; 15: 254-259.
[25] 
Hayduk R., Flodman P., Spence M.A., et al.: HLA haplotypes, polysomnography, and pedigrees in a case series of patients with narcolepsy. Sleep 1997; 20: 850-857.
[26] 
Nevsimalova S., Mignot E., Sonka K., et al.: Familial aspects of narcolepsy-cataplexy in the Czech Republic. Sleep 1997; 20: 1021-1026.
[27] 
Maret S., Tafti M.: Genetics of narcolepsy and other major sleep disorders. Swiss Med Wkly 2005; 135: 662-665.
[28] 
Mignot E.: Genetics of narcolepsy and other sleep disorders. Am J Hum Genet 1997; 60: 1289-1302.
[29] 
Honda M., Honda Y., Uchida S., et al.: Monozygotic twins incompletely concordant for narcolepsy. Biol Psychiatry 2001; 49: 943-947.
[30] 
Partinen M., Hublin C., Kaprio J., et al.: Twin studies in narcolepsy. Sleep 1994; 17: 13-16.
[31] 
Pollmacher T., Schulz H., Geisler P., et al.: DR2-positive monozygotic twins discordant for narcolepsy. Sleep 1990; 13: 336-343.
[32] 
Neely S., Rosenberg R., Spire J.P., et al.: HLA antigens in narcolepsy. Neurology 1987; 37: 1858-1860.
[33] 
Mignot E., Lin L., Rogers W., et al.: Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet 2001; 68: 686-699.
[34] 
Rogers A.E., Meehan J., Guilleminault C., et al.: HLA DR15 (DR2) and DQB1*0602 typing studies in 188 narcoleptic patients with cataplexy. Neurology 1997; 48: 1550-1556.
[35] 
Saper C.B., Scammell T.E., Lu J.: Hypothalamic regulation of sleep and circadian rhythms. Nature 2005; 437: 1257-1263.
[36] 
Sakurai T., Amemiya A., Ishii M., et al.: Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998; 92: 573-585.
[37] 
de Lecea L., Kilduff T.S., Peyron C., et al.: The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A 1998; 95: 322-327.
[38] 
Lin L., Faraco J., Li R., et al.: The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 1999; 98: 365-376.
[39] 
Chemelli R.M., Willie J.T., Sinton C.M., et al.: Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 1999; 98: 437-451.
[40] 
John J., Wu M.F., Boehmer L.N., et al.: Cataplexy-active neurons in the hypothalamus: implications for the role of histamine in sleep and waking behavior. Neuron 2004; 42: 619-634.
[41] 
Mignot E., Nishino S., Sharp L.H., et al.: Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems. J Neurosci 1993; 13: 1057-1064.
[42] 
Peterson P.C., Husain A.M.: Pediatric narcolepsy. Brain Dev 2008; 30: 609-623.
[43] 
Thannickal T.C., Moore R.Y., Nienhuis R., et al.: Reduced number of hypocretin neurons in human narcolepsy. Neuron 2000; 27: 469-474.
[44] 
Peyron C., Faraco J., Rogers W., et al.: A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 2000; 6: 991-997.
[45] 
Ripley B., Overeem S., Fujiki N., et al.: CSF hypocretin/orexin levels in narcolepsy and other neurological conditions. Neurology 2001; 57: 2253-2258.
[46] 
Nishino S., Ripley B., Overeem S., et al.: Hypocretin (orexin) deficiency in human narcolepsy. Lancet 2000; 355: 39-40.
[47] 
Nishino S., Ripley B., Overeem S., et al.: Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy. Ann Neurol 2001; 50: 381-388.
[48] 
Mignot E., Lammers G.J., Ripley B., et al.: The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Arch Neurol 2002; 59: 1553-1562.
[49] 
Dalal M.A., Schuld A., Haack M., et al.: Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients. Neurology 2001; 56: 1749-1751.
[50] 
Kanbayashi T., Yano T., Ishiguro H., et al.: Hypocretin-1 (orexin-A) levels in human lumbar CSF in different age groups: infants to elderly persons. Sleep 2002; 25: 337-339.
[51] 
Tsukamoto H., Ishikawa T., Fujii Y., et al.: Undetectable levels of CSF hypocretin-1 (orexin-A) in two prepubertal boys with narcolepsy. Neuropediatrics 2002; 33: 51-52.
[52] 
Kubota H., Kanbayashi T., Tanabe Y., et al.: Decreased cerebrospinal fluid hypocretin-1 levels near the onset of narcolepsy in 2 prepubertal children. Sleep 2003; 26: 555-557.
[53] 
Aran A., Lin L., Nevsimalova S., et al.: Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset. Sleep 2009; 32: 979-983.
[54] 
Mahlios J., De la Herran-Arita A.K., Mignot E.: The autoimmune basis of narcolepsy. Curr Opin Neurobiol 2013; 23: 767-773.
[55] 
Dale R.C.: Post-streptococcal autoimmune disorders of the central nervous system. Dev Med Child Neurol 2005; 47: 785-791.
[56] 
Nevsimalova S., Jara C., Prihodova I., et al.: Clinical features of childhood narcolepsy. Can cataplexy be foretold? Eur J Paediatr Neurol 2011; 15: 320-325.
[57] 
Han F., Lin L., Li J., et al.: Decreased incidence of childhood narcolepsy 2 years after the 2009 H1N1 winter flu pandemic. Ann Neurol 2013; 73: 560.
[58] 
Wijnans L., Lecomte C., de Vries C., et al.: The incidence of narcolepsy in Europe: before, during, and after the influenza A(H1N1)pdm09 pandemic and vaccination campaigns. Vaccine 2013; 31: 1246-1254.
[59] 
Nohynek H., Jokinen J., Partinen M., et al.: AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland. PLoS One 2012; 7: e33536.
[60] 
Poli F., Overeem S., Lammers G.J., et al.: Narcolepsy as an adverse event following immunization: case definition and guidelines for data collection, analysis and presentation. Vaccine 2013; 31: 994-1007.
[61] 
Overeem S., Black J.L., 3rd, Lammers G.J.: Narcolepsy: immunological aspects. Sleep Med Rev 2008; 12: 95-107.
[62] 
Boehmer L.N., Wu M.F., John J., et al.: Treatment with immunosuppressive and anti-inflammatory agents delays onset of canine genetic narcolepsy and reduces symptom severity. Exp Neurol 2004; 188: 292-299.
[63] 
Hecht M., Lin L., Kushida C.A., et al.: Report of a case of immunosuppression with prednisone in an 8-year-old boy with an acute onset of hypocretin-deficiency narcolepsy. Sleep 2003; 26: 809-810.
[64] 
Dauvilliers Y., Abril B., Mas E., et al.: Normalization of hypocretin-1 in narcolepsy after intravenous immunoglobulin treatment. Neurology 2009; 73: 1333-1334.
[65] 
Dauvilliers Y., Carlander B., Rivier F., et al.: Successful management of cataplexy with intravenous immunoglobulins at narcolepsy onset. Ann Neurol 2004; 56: 905-908.
[66] 
Lecendreux M., Maret S., Bassetti C., et al.: Clinical efficacy of high-dose intravenous immunoglobulins near the onset of narcolepsy in a 10-year-old boy. J Sleep Res 2003; 12: 347-348.
[67] 
Plazzi G., Poli F., Franceschini C., et al.: Intravenous high-dose immunoglobulin treatment in recent onset childhood narcolepsy with cataplexy. J Neurol 2008; 255: 1549-1554.
[68] 
Schatzberg S.J., Cutter-Schatzberg K., Nydam D., et al.: The effect of hypocretin replacement therapy in a 3-year-old Weimaraner with narcolepsy. J Vet Intern Med 2004; 18: 586-588.
[69] 
Stores G.: Recognition and management of narcolepsy. Arch Dis Child 1999; 81: 519-524.
[70] 
Vendrame M., Havaligi N., Matadeen-Ali C., et al.: Narcolepsy in children: a single-center clinical experience. Pediatr Neurol 2008; 38: 314-320.
[71] 
Wise M.S., Lynch J.: Narcolepsy in children. Semin Pediatr Neurol 2001; 8: 198-206.
[72] 
Okun M.L., Lin L., Pelin Z., et al.: Clinical aspects of narcolepsy-cataplexy across ethnic groups. Sleep 2002; 25: 27-35.
[73] 
Silber M.H., Krahn L.E., Olson E.J., et al.: The epidemiology of narcolepsy in Olmsted County, Minnesota: a population-based study. Sleep 2002; 25: 197-202.
[74] 
Benca R.M.: Narcolepsy and excessive daytime sleepiness: diagnostic considerations, epidemiology, and comorbidities. J Clin Psychiatry 2007; 68 Suppl 13: 5-8.
[75] 
Wise M.S.: Narcolepsy and other disorders of excessive sleepiness. Med Clin North Am 2004; 88: 597-610, vii-viii.
[76] 
Kothare S.V., Kaleyias J.: Narcolepsy and other hypersomnias in children. Curr Opin Pediatr 2008; 20: 666-675.
[77] 
Nevsimalova S., Pisko J., Buskova J., et al.: Narcolepsy: clinical differences and association with other sleep disorders in different age groups. J Neurol 2013; 260: 767-775.
[78] 
Harsh J., Peszka J., Hartwig G., et al.: Night-time sleep and daytime sleepiness in narcolepsy. J Sleep Res 2000; 9: 309-316.
[79] 
Scammell T.E.: The neurobiology, diagnosis, and treatment of narcolepsy. Ann Neurol 2003; 53: 154-166.
[80] 
Dahl R.E., Holttum J., Trubnick L.: A clinical picture of child and adolescent narcolepsy. J Am Acad Child Adolesc Psychiatry 1994; 33: 834-841.
[81] 
Thorpy M.J.: Cataplexy associated with narcolepsy: epidemiology, pathophysiology and management. CNS Drugs 2006; 20: 43-50.
[82] 
Krahn L.E., Lymp J.F., Moore W.R., et al.: Characterizing the emotions that trigger cataplexy. J Neuropsychiatry Clin Neurosci 2005; 17: 45-50.
[83] 
Anic-Labat S., Guilleminault C., Kraemer H.C., et al.: Validation of a cataplexy questionnaire in 983 sleep-disorders patients. Sleep 1999; 22: 77-87.
[84] 
Serra L., Montagna P., Mignot E., et al.: Cataplexy features in childhood narcolepsy. Mov Disord 2008; 23: 858-865.
[85] 
Overeem S., Mignot E., van Dijk J.G., et al.: Narcolepsy: clinical features, new pathophysiologic insights, and future perspectives. J Clin Neurophysiol 2001; 18: 78-105.
[86] 
de Zambotti M., Pizza F., Covassin N., et al.: Facing emotions in narcolepsy with cataplexy: haemodynamic and behavioural responses during emotional stimulation. J Sleep Res 2014; 23: 432-440.
[87] 
Pizza F., Franceschini C., Peltola H., et al.: Clinical and polysomnographic course of childhood narcolepsy with cataplexy. Brain 2013; 136: 3787-3795.
[88] 
Plazzi G., Pizza F., Palaia V., et al.: Complex movement disorders at disease onset in childhood narcolepsy with cataplexy. Brain 2011; 134: 3477-3489.
[89] 
Kandt R.S., Emerson R.G., Singer H.S., et al.: Cataplexy in variant forms of Niemann-Pick disease. Ann Neurol 1982; 12: 284-288.
[90] 
Parkes J.D.: Genetic factors in human sleep disorders with special reference to Norrie disease, Prader-Willi syndrome and Moebius syndrome. J Sleep Res 1999; 8 Suppl 1: 14-22.
[91] 
Martinez-Rodriguez J.E., Lin L., Iranzo A., et al.: Decreased hypocretin-1 (Orexin-A) levels in the cerebrospinal fluid of patients with myotonic dystrophy and excessive daytime sleepiness. Sleep 2003; 26: 287-290.
[92] 
Zarowski M., Steinborn B., Gurda B., et al.: Treatment of cataplexy in Niemann-Pick disease type C with the use of miglustat. Eur J Paediatr Neurol 2011; 15: 84-87.
[93] 
Pedroso J.L., Fusao E.F., Ladeia-Frota C., et al.: Teaching video neuroimages: gelastic cataplexy as the first neurologic manifestation of Niemann-Pick disease type C. Neurology 2012; 79: e189.
[94] 
Girard T.A., Cheyne J.A.: Timing of spontaneous sleep-paralysis episodes. J Sleep Res 2006; 15: 222-229.
[95] 
Kales A., Cadieux R.J., Soldatos C.R., et al.: Narcolepsy-cataplexy. I. Clinical and electrophysiologic characteristics. Arch Neurol 1982; 39: 164-816.
[96] 
Goode G.B.: Sleep paralysis. Arch Neurol 1962; 6: 228-234.
[97] 
Guilleminault C., Pelayo R.: Narcolepsy in prepubertal children. Ann Neurol 1998; 43: 135-142.
[98] 
Sturzenegger C., Bassetti C.L.: The clinical spectrum of narcolepsy with cataplexy: a reappraisal. J Sleep Res 2004; 13: 395-406.
[99] 
Stores G.: The protean manifestations of childhood narcolepsy and their misinterpretation. Dev Med Child Neurol 2006; 48: 307-310.
[100] 
Plazzi G., Serra L., Ferri R.: Nocturnal aspects of narcolepsy with cataplexy. Sleep Med Rev 2008; 12: 109-128.
[101] 
Dauvilliers Y., Rompre S., Gagnon J.F., et al.: REM sleep characteristics in narcolepsy and REM sleep behavior disorder. Sleep 2007; 30: 844-849.
[102] 
Vandeputte M., de Weerd A.: Sleep disorders and depressive feelings: a global survey with the Beck depression scale. Sleep Med 2003; 4: 343-345.
[103] 
Chakravorty S.S., Rye D.B.: Narcolepsy in the older adult: epidemiology, diagnosis and management. Drugs Aging 2003; 20: 361-376.
[104] 
Billiard M., Bassetti C., Dauvilliers Y., et al.: EFNS guidelines on management of narcolepsy. Eur J Neurol 2006; 13: 1035-1048.
[105] 
Dahmen N., Becht J., Engel A., et al.: Prevalence of eating disorders and eating attacks in narcolepsy. Neuropsychiatr Dis Treat 2008; 4: 257-261.
[106] 
Kotagal S., Krahn L.E., Slocumb N.: A putative link between childhood narcolepsy and obesity. Sleep Med 2004; 5: 147-150.
[107] 
Peraita-Adrados R., Garcia-Penas J.J., Ruiz-Falco L., et al.: Clinical, polysomnographic and laboratory characteristics of narcolepsy-cataplexy in a sample of children and adolescents. Sleep Med 2011; 12: 24-27.
[108] 
Chabas D., Foulon C., Gonzalez J., et al.: Eating disorder and metabolism in narcoleptic patients. Sleep 2007; 30: 1267-1273.
[109] 
Baker T.L., Guilleminault C., Nino-Murcia G., et al.: Comparative polysomnographic study of narcolepsy and idiopathic central nervous system hypersomnia. Sleep 1986; 9: 232-242.
[110] 
Luc M.E., Gupta A., Birnberg J.M., et al.: Characterization of symptoms of sleep disorders in children with headache. Pediatr Neurol 2006; 34: 7-12.
[111] 
Dahmen N., Kasten M., Wieczorek S., et al.: Increased frequency of migraine in narcoleptic patients: a confirmatory study. Cephalalgia 2003; 23: 14-19.
[112] 
Dahmen N., Querings K., Grun B., et al.: Increased frequency of migraine in narcoleptic patients. Neurology 1999; 52: 1291-1293.
[113] 
Littner M.R., Kushida C., Wise M., et al.: Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test. Sleep 2005; 28: 113-121.
[114] 
Bradshaw D.A., Yanagi M.A., Pak E.S., et al.: Nightly sleep duration in the 2-week period preceding multiple sleep latency testing. J Clin Sleep Med 2007; 3: 613-619.
[115] 
Hoddes E., Zarcone V., Smythe H., et al.: Quantification of sleepiness: a new approach. Psychophysiology 1973; 10: 431-436.
[116] 
Johns M.W.: A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 1991; 14: 540-545.
[117] 
Drake C., Nickel C., Burduvali E., et al.: The pediatric daytime sleepiness scale (PDSS): sleep habits and school outcomes in middle-school children. Sleep 2003; 26: 455-458.
[118] 
Carskadon M.A., Dement W.C., Mitler M.M., et al.: Guidelines for the multiple sleep latency test (MSLT): a standard measure of sleepiness. Sleep 1986; 9: 519-524.
[119] 
Nevsimalova S., Prihodova I., Kemlink D., et al.: REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy. Sleep Med 2007; 8: 784-786.
[120] 
Kothare S.V., Kaleyias J.: The clinical and laboratory assessment of the sleepy child. Semin Pediatr Neurol 2008; 15: 61-69.
[121] 
Arand D., Bonnet M., Hurwitz T., et al.: The clinical use of the MSLT and MWT. Sleep 2005; 28: 123-144.
[122] 
Kotagal S., Hartse K.M., Walsh J.K.: Characteristics of narcolepsy in preteenaged children. Pediatrics 1990; 85: 205-209.
[123] 
Mitler M.M., Doghramji K., Shapiro C.: The maintenance of wakefulness test: normative data by age. J Psychosom Res 2000; 49: 363-365.
[124] 
Zandieh S., Ramgopal S., Khatwa U., et al.: The maintenance of wakefulness test in pediatric narcolepsy. Pediatr Neurol 2013; 48: 443-446.
[125] 
Mignot E., Young T., Lin L., et al.: Nocturnal sleep and daytime sleepiness in normal subjects with HLA-DQB1*0602. Sleep 1999; 22: 347-352.
[126] 
Dauvilliers Y., Arnulf I., Mignot E.: Narcolepsy with cataplexy. Lancet 2007; 369: 499-511.
[127] 
Honda Y., Juji T., Matsuki K., et al.: HLA-DR2 and Dw2 in narcolepsy and in other disorders of excessive somnolence without cataplexy. Sleep 1986; 9: 133-142.
[128] 
Mignot E., Hayduk R., Black J., et al.: HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients. Sleep 1997; 20: 1012-1020.
[129] 
Mitler M.M., Carskadon M.A., Czeisler C.A., et al.: Catastrophes, sleep, and public policy: consensus report. Sleep 1988; 11: 100-109.
[130] 
Findley L.J., Suratt P.M., Dinges D.F.: Time-on-task decrements in „steer clear” performance of patients with sleep apnea and narcolepsy. Sleep 1999; 22: 804-809.
[131] 
Broughton R., Ghanem Q., Hishikawa Y., et al.: Life effects of narcolepsy in 180 patients from North America, Asia and Europe compared to matched controls. Can J Neurol Sci 1981; 8: 299-304.
[132] 
Thorpy M.: Therapeutic advances in narcolepsy. Sleep Med 2007; 8: 427-440.
[133] 
Wise M.S.: Childhood narcolepsy. Neurology 1998; 50: 37-42.
[134] 
Rogers A.E., Aldrich M.S., Lin X.: A comparison of three different sleep schedules for reducing daytime sleepiness in narcolepsy. Sleep 2001; 24: 385-391.
[135] 
Mullington J., Broughton R.: Scheduled naps in the management of daytime sleepiness in narcolepsy-cataplexy. Sleep 1993; 16: 444-456.
[136] 
Wise M.S., Arand D.L., Auger R.R., et al.: Treatment of narcolepsy and other hypersomnias of central origin. An American Academy of Sleep Medicine Review. Sleep 2007; 30: 1712-1727.
[137] 
Husain A.M., Yancy W.S., Jr., Carwile S.T., et al.: Diet therapy for narcolepsy. Neurology 2004; 62: 2300-2302.
[138] 
Littner M., Johnson S.F., McCall W.V., et al.: Practice parameters for the treatment of narcolepsy: an update for 2000. Sleep 2001; 24: 451-466.
[139] 
Mitler M.M., Shafor R., Hajdukovich R., et al.: Treatment of narcolepsy: objective studies on methylphenidate, pemoline, and protriptyline. Sleep 1986; 9: 260-264.
[140] 
Greenhill L.L., Biederman J., Boellner S.W., et al.: A randomized, double-blind, placebo-controlled study of modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2006; 45: 503-511.
[141] 
Shindler J., Schachter M., Brincat S., et al.: Amphetamine, mazindol, and fencamfamin in narcolepsy. Br Med J (Clin Res Ed) 1985; 290: 1167-1170.
[142] 
Mitler M.M., Hajdukovic R., Erman M., et al.: Narcolepsy. J Clin Neurophysiol 1990; 7: 93-118.
[143] 
Mitler M.M., Hajdukovic R., Erman M.K.: Treatment of narcolepsy with methamphetamine. Sleep 1993; 16: 306-317.
[144] 
Parkes J.D., Dahlitz M.: Amphetamine prescription. Sleep 1993; 16: 201-203.
[145] 
Knoll J.: Deprenyl (selegiline): the history of its development and pharmacological action. Acta Neurol Scand Suppl 1983; 95: 57-80.
[146] 
Kuran W.: [ Selegiline (Jumex) in the treatment of narcolepsy]. Neurol Neurochir Pol 1993; 27: 131-133.
[147] 
Mayer G., Ewert Meier K., Hephata K.: Selegeline hydrochloride treatment in narcolepsy. A double-blind, placebo-controlled study. Clin Neuropharmacol 1995; 18: 306-319.
[148] 
Reinish L.W., MacFarlane J.G., Sandor P., et al.: REM changes in narcolepsy with selegiline. Sleep 1995; 18: 362-367.
[149] 
Boivin D.B., Montplaisir J., Petit D., et al.: Effects of modafinil on symptomatology of human narcolepsy. Clin Neuropharmacol 1993; 16: 46-53.
[150] 
Billiard M., Besset A., Montplaisir J., et al.: Modafinil: a double-blind multicentric study. Sleep 1994; 17: 107-112.
[151] 
Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy. US Modafinil in Narcolepsy Multicenter Study Group. Ann Neurol 1998; 43: 88-97.
[152] 
Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy: US Modafinil in Narcolepsy Multicenter Study Group. Neurology 2000; 54: 1166-1175.
[153] 
Dinges D.F., Arora S., Darwish M., et al.: Pharmacodynamic effects on alertness of single doses of armodafinil in healthy subjects during a nocturnal period of acute sleep loss. Curr Med Res Opin 2006; 22: 159-167.
[154] 
Harsh J.R., Hayduk R., Rosenberg R., et al.: The efficacy and safety of armodafinil as treatment for adults with excessive sleepiness associated with narcolepsy. Curr Med Res Opin 2006; 22: 761-774.
[155] 
Laborit H.: [Correlations between protein synthesis and serotonin in various activities of the central nervous system. (Slow and desynchronized sleep, learning and memory, sexual activity, morphine tolerance, aggressivity, Na gammahydroxybutyrate pharmacology]. Agressologie 1971; 12: 9-23.
[156] 
Mamelak M., Escriu J.M., Stokan O.: Sleep-inducing effects of gammahydroxybutyrate. Lancet 1973; 2: 328-329.
[157] 
Mamelak M., Webster P.: Treatment of narcolepsy and sleep apnea with gammahydroxybutyrate: a clinical and polysomnographic case study. Sleep 1981; 4: 105-111.
[158] 
Broughton R., Mamelak M.: Effects of nocturnal gamma-hydroxybutyrate on sleep/waking patterns in narcolepsy-cataplexy. Can J Neurol Sci 1980; 7: 23-31.
[159] 
Scrima L., Hartman P.G., Johnson F.H., Jr., et al.: The effects of gamma-hydroxybutyrate on the sleep of narcolepsy patients: a double-blind study. Sleep 1990; 13: 479-490.
[160] 
Lammers G.J., Arends J., Declerck A.C., et al.: Gammahydroxybutyrate and narcolepsy: a double-blind placebo-controlled study. Sleep 1993; 16: 216-220.
[161] 
Frenette E., Kushida C.A.: Primary hypersomnias of central origin. Semin Neurol 2009; 29: 354-367.
[162] 
Guilleminault C., Raynal D., Takahashi S., et al.: Evaluation of short-term and long-term treatment of the narcolepsy syndrome with clomipramine hydrochloride. Acta Neurol Scand 1976; 54: 71-87.
[163] 
Shapiro W.R.: Treatment of Cataplexy with Clomipramine. Arch Neurol 1975; 32: 653-656.
[164] 
Dauvilliers Y., Billiard M., Montplaisir J.: Clinical aspects and pathophysiology of narcolepsy. Clin Neurophysiol 2003; 114: 2000-2017.
[165] 
Langdon N., Shindler J., Parkes J.D., et al.: Fluoxetine in the treatment of cataplexy. Sleep 1986; 9: 371-373.
[166] 
Abad V.C., Guilleminault C.: Emerging drugs for narcolepsy. Expert Opin Emerg Drugs 2004; 9: 281-291.
[167] 
Mignot E., Nishino S.: Emerging therapies in narcolepsy-cataplexy. Sleep 2005; 28: 754-763.
[168] 
Mieda M., Willie J.T., Hara J., et al.: Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice. Proc Natl Acad Sci U S A 2004; 101: 4649-4654.
[169] 
John J., Wu M.F., Siegel J.M.: Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs. Sleep Res Online 2000; 3: 23-28.
[170] 
Arias-Carrion O., Murillo-Rodriguez E.: Cell transplantation: a future therapy for narcolepsy? CNS Neurol Disord Drug Targets 2009; 8: 309-314.
[171] 
Arias-Carrion O., Drucker-Colin R., Murillo-Rodriguez E.: Survival rates through time of hypocretin grafted neurons within their projection site. Neurosci Lett 2006; 404: 93-97.
[172] 
Arias-Carrion O., Murillo-Rodriguez E., Xu M., et al.: Transplantation of hypocretin neurons into the pontine reticular formation: preliminary results. Sleep 2004; 27: 1465-1470.
[173] 
Chen W., Black J., Call P., et al.: Late-onset narcolepsy presenting as rapidly progressing muscle weakness: response to plasmapheresis. Ann Neurol 2005; 58: 489-490.
[174] 
Barbier A.J., Berridge C., Dugovic C., et al.: Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol 2004; 143: 649-661.
[175] 
Tedford C.E., Phillips J.G., Gregory R., et al.: Development of trans-2-[1H-imidazol-4-yl] cyclopropane derivatives as new high-affinity histamine H3 receptor ligands. J Pharmacol Exp Ther 1999; 289: 1160-1168.
[176] 
Riehl J., Honda K., Kwan M., et al.: Chronic oral administration of CG-3703, a thyrotropin releasing hormone analog, increases wake and decreases cataplexy in canine narcolepsy. Neuropsychopharmacology 2000; 23: 34-45.
[177] 
Nishino S., Arrigoni J., Shelton J., et al.: Effects of thyrotropin-releasing hormone and its analogs on daytime sleepiness and cataplexy in canine narcolepsy. J Neurosci 1997; 17: 6401-6408.
[178] 
Broberger C., McCormick D.A.: Excitatory effects of thyrotropin-releasing hormone in the thalamus. J Neurosci 2005; 25: 1664-1673.
Powrót
 

Najczęsciej pobierane
Semiologiczna i psychiatryczna charakterystyka dzieci z psychogennymi napadami rzekomopadaczkowymi
Neurol Dziec 2018; 27, 55: 11-14
Autyzm dziecięcy – współczesne spojrzenie
Neurol Dziec 2010; 19, 38: 75-78
Obraz bólów głowy w literaturze pięknej i poezji na podstawie wybranych utworów
Neurol Dziec 2016; 25, 50: 9-17

Narzędzia artykułu
Manager cytowań
Format:

Scholar Google
Artykuły aut.:Żarowski M
Artykuły aut.:Steinborn B
Artykuły aut.:Kothare SV

PubMed
Artykuły aut.:Żarowski M
Artykuły aut.:Steinborn B
Artykuły aut.:Kothare SV


Copyright © 2017 by Polskie Towarzystwo Neurologów Dziecięcych